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KMID : 0356619920070040331
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Journal of Korean Society of Endocrinology
1992 Volume.7 No. 4 p.331 ~ p.342
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Thyrotropin Secreating Pituitray Adenoma
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이은직
김경래/김현만/정윤석/안광진/이경미/임승길/이현철/김덕희
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Abstract
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TSH secreting pituitary adenoma is a rare disorder and represents about 1% of all pituitary adenomas. About 80 cases have so far been reported. We experienced four cases of TSH secreting pituitary adenoma. Three of them were macroadenomas and 1
was
microadenoma. Serum TSH levels varied between 4. 1~185 uIU/ml. The serum a-subunit levels of two patients tested were slightly elevated (0.87, 0.96 mIU/ml). Serum TSH and a-subunit response to TSH, dexamethasone. T3, bromocriptine, and octreotide
were
variable when studied. Three patients underwent transsphenoidal microsurgery. The removed tumor tissue were composed of thyrotropes revealed by immunocytochemistry. One of then received radiotherapy. They were cured. Treatment with octreotide in
1
patient who did not received surgery resulted in normalization of serum TSH and thyroid hormone levels and reduction in tumor size. (J Kor Soc Endocrinol 7:331~342, 1992).
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